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Concordance of Immunohistochemistry Reactivity Between Core Needle and Corresponding Mastectomy Specimens in Breast Cancer Patients.


Melody S. Rosales

Related Institution

Department of Pathology - Baguio General Hospital & Medical Center

Publication Information

Publication Type
Research Report
September 1, 2019-August 31, 2020


Introduction: Core needle biopsy (CNB) had an important role in breast cancer detection and provision of information to determine therapeutic approach through immunohistochemistry (IHC) evaluation. However, many questioned the reliability of core needle biopsy due to tumor heterogeneity and small biopsy size. Variability in the concordance of estrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor - 2 (Her2) determination were seen worldwide and possibly inaccurate up to 20%. Thus, the aim of the study was to determine the concordance rates of breast immunohistochemistry reactivity (ER, PR, Her2) between core needle biopsy and corresponding mastectomy specimens in patients with breast cancer.

Methods: A one-year cross-sectional study was conducted on 31 breast cancer patients in Baguio General Hospital and Medical Center from September 1, 2019 to August 31, 2020. Patients underwent CNB and definitive surgery. To evaluate the concordance of ER, PR and Her-2 status, CNB and corresponding mastectomy specimens were immunohistochemically tested, assessed and compared. A detailed explanation was made and consent from each patient was obtained before testing for immunohistochemistry.

Results: In total, 31 patients were eligible for the study. Of which, majority, represented by 8 (25.81%) participants belonged to age bracket 39-45 years old, 20 (64.52%) specimens involved the left breast, 16 (51.61%) were diagnosed with Stage IIA breast cancer. The concordance rates of CNB and corresponding mastectomy specimens were 87.88% for ER and PR and 77.14% for Her-2.

Conclusion: This study showed that CNB had an excellent concordance with mastectomy specimens for ER and PR immunohistochemistry status, however, it should be cautiously used for Her-2 status especially if it had 1+ or 2+ Her-2 grade.


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