Herschel Charisse C. Rivera
Department of Obstetrics and Gynecology - Baguio General Hospital and Medical Center - Department of Health
March 1, 2019-April 1, 2020
OBJECTIVES: To determine the diagnostic value of mean platelet volume (MPV) in predicting the development of preeclampsia among primigravid parturients, and to determine the sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) of MPV as a test to predict the occurrence of preeclampsia among primigravid parturients.
METHODS: All participants were tested for complete blood count (CBC) including MPV. Blood extractions for the determination of CBC and MPV were done at less than 13 weeks age of gestation (AOG), on the 16th to 18th week AOG, and at the 24th to 26th week AOG, respectively. The MPV during each determination were classified as elevated or non-elevated and correlated to the development of pre-eclampsia. The sensitivity, specificity, PPV and NPV of MPV at less than 13 weeks AOG, at the 16th to 18th week AOG, and at 24 to 26 weeks AOG in predicting the development of pre-eclampsia were analyzed.
RESULTS: There were 116 patients who participated in the study. Most of the participants are 26 to 29 years of age. The body mass index was noted to be not statistically significant among the participants who developed and did not develop pre-eclampsia. The percentage of participants with a family history of hypertension who eventually developed pre-eclampsia were noted to be 51.72%. At less than 13 weeks AOG, MPV has high specificity (100%) but low sensitivity (25.86%) in predicting the development of pre-eclampsia. At 16 to 18 weeks (AOG) and at 24 to 26 weeks (AOG), the sensitivity (98.27% and 94.82%, respectively), specificity (100% for both groups of gestations), PPV (100% for both groups of gestations), and NPV (98.3% and 95.08%, respectively) of MPV in predicting the development of preeclampsia are high.
CONCLUSION: An increase in MPV predicts future occurrence of pre-eclampsia most accurately at 16 to 18 weeks AOG where the sensitivity (98.27%), specificity (100%), positive predictive value (100%) and negative predictive value (98.3%) are high.
Keywords: primigravid, parturients, pre-eclampsia, mean platelet volume, sensitivity, specificity, positive predictive value , negative predictive value
1. Cunningham,, Gary . Kenneth LevenoWilliam’s Obstetrics. McGraw-Hill Education, 2018. (25)
2. Bhide, Amarath . Reed Elsevier. Aria’s Practical Guide to High Risk Pregnancy and delivery, A South Asian Perspective. India: Reed Elsevier, 2015. (4th)
3. Kirbas, Ayse . "Prediction of Preeclampsia by First Trimester Combined Test and Simple Complete Blood Count Parameters" Journal of Clinical and Diagnostic Research
9, QC20-qc@#, November 2015. Retrieved from: http://DOI: 10. 7860/JCDR/2015/1539.6833.
4. Burak, Yucel . "Neutrophil to lymphocyte ratio, platelet to lymphocyte ratio, mean platelet volume, red cell distribution width and plateletcrit in preecclampsia" An international Journal of Women’s cardiovascular Health
7, 29-32, 2017. Retrieved from: http://www.elvesier.com/locate/preghy
5. Mehmet Aa, Akil . "Mean Platelet Volume and Neutrophil Lymphocyte Ratio as New Markers of Preeclampsia Severity" Kosuyolu Heart Journal
, 84-88, 2015. Retrieved from: http://DOI 10. 5578/khj.9852