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EVALUATION OF PLATELET INDICES IN WOMEN WITH FIRST TRIMESTER MISCARRIAGE.

Related Institution

Department of Pathology - Baguio General Hospital and Medical Center - Department of Health

Publication Information

Publication Type
Research Report
Date
September 1, 2019-August 31, 2020

Abstract

INTRODUCTION: More than 80% of pregnancy loss occur in the first trimester and no apparent etiology can be identified 50-70% of cases. Successful implantation requires a receptive endometrium aided by trophoblasts and platelet activation in the implantation site. Activated platelets undergo morphological changes which can be measured by automated hematology analyzers. These changes, collectively known as platelet indices (PIs), include mean platelet volume (MPV), plateletcrit (PCT), and platelet distribution width (PDW). These changes in platelet morphology affects successful implantation. OBJECTIVES: This study aimed to determine the PIs (MPV, PCT, PDW) of pregnant women with first trimester abortion versus pregnant women who delivered successfully and to determine if PIs could be predictors of pregnancy loss. MATERIALS AND METHODS: This is a case-control study. The total sample size computed using the OpenEpi software is 328 which is available online with 164 for cases and 164 controls. The PIs were measured by Mindray BC-6800 Hematology Analyzer and were retrieved from the Laboratory Information System of the Department of Pathology. RESULTS: Patients with first trimester abortion have significantly lower MPV compared to the control group. However, there is no significant difference in the PCT and PDW between patients with first trimester abortion and the control group. Furthermore, MPV is also a significant predictor of pregnancy loss. The negative value of  beta-coefficient computed as -0.913 indicates that as MPV decreases, the odds of abortion increases. This was also manifested by the odds ratio being <1 (0.401). CONCLUSION: This study concludes that there is an increasing evidence that MPV can be a predictor of pregnancy loss. Its use can be of great help in clinical practice as they are readily generated by hematology analyzers without additional cost.

References

1. Hennessy, M , Dennehy, R , Meaney, S . Clinical Practice Guidelines for Recurrent Miscarriage in High-Income Countries: A Systematic ReviewReproductive BioMedicine Online Journal 42(6): June 2021
2. Burke, N , Flood, K , Murray, A . Platelet Reactivity Changes Significantly Throughout All Trimesters of Pregnanc Compared with the Nonpregnant State: A Prospective StudyAn International Journal of Obstetrics and Gynecology 120(13): August 2013
3. Mor, G , Cardenas, I , Abrahams, V . Inflammation and Pregnancy: The Role of the Immune System at the Implantation SiteAnnals of the New York Academy of Sciences 1221(1): March 2011

Physical Location

LocationLocation CodeAvailable FormatAvailability
Baguio General Hospital 2600 Abstract Print Format

 
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